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 Thomas Huckle Weller was an American virologist and a Nobel Prize winner.
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John Bennett Fenn15.6.1917

Wikipedia (05 Jun 2013, 09:37)

John Bennett Fenn (June 15, 1917 – December 10, 2010) was an American research professor of analytical chemistry who was awarded a share of the Nobel Prize in Chemistry in 2002. Fenn shared half of the award with Koichi Tanaka for their work in mass spectrometry. The other half of the 2002 award went to Kurt Wüthrich. Fenn's contributions specifically related to the development of electrospray ionization, now a commonly used technique for large molecules and routine liquid chromatography-tandem mass spectrometry. Early in his career, Fenn did research in the field of jet propulsion at Project SQUID, and focused on molecular beam studies. Fenn finished his career with more than 100 publications, including one book.

Fenn was born in New York City, and moved to Kentucky with his family during the Great Depression. Fenn did his undergraduate work at Berea College, and received his Ph.D. from Yale. He worked in industry at Monsanto and at private research labs before moving to academic posts including Yale and Virginia Commonwealth University.

Fenn's research into electrospray ionization found him at the center of a legal dispute with Yale University. He lost the lawsuit, after it was determined that he misled the university about the potential usefulness of the technology. Yale was awarded $500,000 in legal fees and $545,000 in damages. The decision pleased the university, but provoked mixed responses from some people affiliated with the institution, who were disappointed with the treatment of a Nobel Prize winner with such a long history at the school.

Research career and academic posts

After completing graduate school, Fenn's first job was with Monsanto, working in the Phosphate Division and producing polychlorinated biphenyls (PCBs). Fenn and his colleague James Mullen became disenchanted with the direction of work at Monsanto, and they resigned together in 1943. Fenn worked briefly at a small company named Sharples Chemicals that focused on the production of amyl chloride derivatives. In 1945, he joined Mullen at his new startup, Experiment, Inc, focusing on research and development. Fenn's first publication came in 1949 as a result of his work with Mullen. That this publication came ten years after he completed graduate school made Fenn somewhat of a rarity amongst academics.

In 1952, Fenn moved to Princeton University as Director of Project SQUID, a program to support research related to jet propulsion that was funded by the Office of Naval Research. During this period, Fenn started his work developing supersonic atomic and molecular beam sources, which are now widely used in chemical physics research. After working with Project SQUID, Fenn returned to Yale University in 1967. He held a joint appointment in the chemistry and engineering departments until 1987, conducting much of his research in Mason Laboratory. In 1987, Fenn had reached Yale's mandatory retirement age. He became a professor emeritus, entitling him to office space at the university, but costing him most of his laboratory space and research assistants.

After a dispute with Yale over his forced retirement and the rights to his invention of electrospray ionization, Fenn moved to Richmond, Virginia to join Virginia Commonwealth University's (VCU) Department of Chemistry as an analytical chemistry professor. VCU established an engineering department in the late 1990s, and Fenn held a joint professorship between the two departments until his death. Even in his 80s, Fenn enjoyed the opportunity to be in the lab doing research, saying, "I like to mingle and exchange with the young people. It gets me out from underfoot at home."

Research interests

While Fenn was working with Monsanto, the company's research was focused on the production of phosphoric acid and polychlorinated biphenyls (PCBs). Fenn and his colleagues at Monsanto were largely unaware of the health hazards posed by PCBs, indeed because of their inertness, they "practically bathed in the stuff". After spending several more years doing various industrial research, Fenn was looking to get back into the academic world. He had the opportunity to go to Princeton University, where he became the director of Project SQUID.

Fenn did not start his Nobel-winning research until later in his career. He was semi-retired when he first published his research on electrospray ionization for mass spectrometry. Fenn felt that his work in electrospray ionization received "a kick in the pants" when proteomics emerged. In 2001, more than 1700 papers on proteomics were published, many using electrospray ionization. Electrospray ionization provides a way to get accurate information about the mass of a large molecule very quickly, even when it is in a mixture of other molecules. The liquid sample is introduced into an electrospray source (at atmospheric pressure) and desolvated with a flow of heated nitrogen gas. This forms small droplets which evaporate in a region under vacuum, which increases the charge on the droplets. For large molecules like proteins, this often results in multiply charge species. Increasing the charge on the molecules, decreased the mass to charge ratio, which allows the mass to be more easily determined.

Despite getting a late start in publishing his research (he did not publish a paper until 10 years after finishing graduate school), Fenn had over 100 publications at the time of his death. He also wrote a book, entitled Engines, Energy, and Entropy: A Thermodynamics Primer. The Chemical Heritage Foundation Museum in Philadelphia, PA has the instrument Fenn and his graduate students built while they were developing electrospray ionization on display, after receiving it as a gift from Fenn.

Nobel Prize

Fenn shared the 2002 Nobel Prize in Chemistry with Koichi Tanaka and Kurt Wüthrich "for the development of methods for identification and structure analyses of biological macromolecules." Fenn and Tanaka split half of the award for their work in developing ionization techniques for using mass spectrometry to analyze large biological molecules. Wüthrich was honored for his work in developing nuclear magnetic resonance techniques to analyze similar molecules in solution. Fenn was honoured largely for his contributions to the development of electrospray ionization, which made the analysis of large molecules by mass spectrometry feasible. Fenn's Nobel lecture after being presented with the award was entitled "Electrospray Wings for Molecular Elephants.' He was surprised by his selection as a Nobel winner, saying "It’s like winning the lottery, I’m still in shock." At the time of his award, Fenn was working at Virginia Commonwealth University.

Other awards

Fenn received his Nobel Prize fairly late in his career. Prior to being honored by the Nobel Foundation, Fenn had received numerous other awards. Early in his career, Fenn's research was focused on molecular beams, leading him to be named an honorary president of the Sixth International Symposium on Molecular Beams in 1977, and the first fellow of the International Molecular Beam Symposium in 1985. In 1982, the Alexander von Humboldt Foundation presented him with their U.S. Senior Scientist Award.

Fenn's work in mass spectrometry earned him another spate of awards later in his career. In 1992, the American Society for Mass Spectrometry presented him with their Award for Distinguished Contributions in Mass Spectrometry. The International Society of Mass Spectrometry honored him with the Thomson Medal in 2000, and in the same year the American Chemical Society presented him with the Award for Advancements in Chemical Instrumentation. He was awarded the Association of Biomolecular Resource Facilities Award for outstanding contributions to Biomolecular Technologies in 2002. In 2003, Fenn was honored by his alma mater with the Wilbur Cross Medal, the Yale Graduate School Alumni Association's highest honor.

Fenn maintained numerous professional affiliations, including membership in the American Chemical Society, the American Society for Mass Spectrometry, Sigma Chi, the American Association of University Professors and the Alexander von Humboldt Association of America. In 2000, Fenn was made a fellow of the American Academy of Arts and Sciences and in 2003 he was elected to the National Academy of Sciences

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