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Apollo 8, the second manned mission in the United States Apollo space program, was launched on December 21, 1968, and became the first manned spacecraft to leave Earth orbit, reach the Earth's Moon, orbit it and return safely to Earth. The three-astronaut crew — Commander Frank Borman, Command Module Pilot James Lovell, and Lunar Module Pilot William Anders — became the first humans to travel beyond low Earth orbit, the first to see Earth as a whole planet, and then the first to directly see the far side of the Moon. The 1968 mission, the third flight of the Saturn V rocket and the first manned launch of the Saturn V, was also the first manned launch from the John F. Kennedy Space Center, Florida, located adjacent to Cape Canaveral.

Originally planned as a second Lunar Module/Command Module test in an elliptical medium Earth orbit in early 1969, the mission profile was changed in August 1968 to a more ambitious Command Module-only lunar-orbital flight to be flown in December, because the Lunar Module (LM) was not yet ready to make its first flight. This meant Borman's crew was scheduled to fly two to three months sooner than originally planned, leaving them a shorter time for training and preparation, thus placing more demands than usual on their time and discipline.

Apollo 8 took three days to travel to the Moon. It orbited ten times over the course of 20 hours, during which the crew made a Christmas Eve television broadcast in which they read the first 10 verses from the Book of Genesis. At the time, the broadcast was the most watched television program ever. Apollo 8's successful mission paved the way for Apollo 11 to fulfill U.S. President John F. Kennedy's goal of landing a man on the Moon before the end of the 1960s. The Apollo 8 astronauts returned to Earth on December 27, 1968, when their spacecraft splashed down in the Northern Pacific Ocean.